Meet Renee Sendelbach

Hi, I’m Renee Sendelbach

Mother, Artist, Author, Speaker and Metastatic Breast Cancer Thriver

I have always hated that statement, “So, tell me about yourself.” … Maybe that is why I never ever fit into corporate America?!?!

The short story of me is that I am in my 40’s living with Stage IV breast cancer.

The long story of me is that I am a lover of God and am in awe of Him daily, a wife, a mommy, a daughter, a sister, a friend, an artist, writer, author and fighter–there is no way I am going down without a fight!

I want to share my life here with you for many reasons–to show people that a Stage IV diagnosis is not an instant death sentence, to help people realize that every person is battling something–even if they look great on the outside–we have no idea what is going on inside, and empathy and love is built into us for a reason–TO USE IT!

I believe in God, I believe in Him sending us Angels, people and help in anyway He can.

I am a horrible speller. Sorry up front if this annoys you–I would claim chemo brain but it has been this way all my life. If I say I will do something and I don’t, please don’t get offended–I will claim chemo brain on this one… or that I can be a flake–I really don’t mean to be.

I hope you join me here on this journey I call life here in my own Cancerland–yes, like Alice in Wonderland!


My Cancer Timeline

Click on the date to read more about my journey in Cancerland.

I found a lump in my right breast.

August, 2008:

I found a lump in my right breast.

Stage 1, Triple Negative Breast Cancer

September, 2008:

After many tests, it was determined to be Stage 1, triple negative breast cancer

Chemo Treatments

October 6, 2008 – November 17, 2008:

I received 4 chemo treatments – one every other Monday.

Adriamycin doxorubicin and Cytoxan cyclophosphamide make up the chemotherapy regimen known as AC.

Adriamycin is administered first, followed by Cytoxan.

Cytoxan is a clear fluid once mixed, and Adriamycin is noted for being bright red. Adriamycin and Cytoxan are both given intravenously.

Medications designed to prevent side effects are given before treatment. Administration of the chemotherapy is typically done in about an hour. 

Read more: http://www.livestrong.com/article/116572-ac-chemotherapy-breast-cancer/#ixzz2WBwallv1

Started Second Chemo: Taxol

December 2008 through January 8, 2009:

Started second chemo.

Taxol

How Taxol Is Given:

  • Taxol is given as an injection or infusion into the vein (intravenous, IV). 
  • Taxol is an irritant.  An irritant is a chemical that can cause inflammation of the vein through which it is given.  If the medication escapes from the vein it can cause tissue damage.  The nurse or doctor who gives Taxol must be carefully trained.  If you experience pain or notice redness or swelling at the IV site while you are receiving Taxol, alert your health care professional immediately. 
  • Because severe allergic reactions have occurred in some people taking Taxol, you will be asked to take medications to help prevent a reaction.  Your doctor will prescribe the exact regimen.
  • Taxol is given over various amounts of times and in various schedules. 
  • There is no pill form of Taxol.

Lumpectomy

February, 2009:

Lumpectomy – all margins were clear.

Port-a-cath removed,

Radiation Treatments

March 9, 2009 – May 1, 2009:

37 radiation treatments

I was deemed CANCER FREE!!

CT Scan Results… Not Good

March 8, 2011:

I received a call from my oncologist with my yearly CT scan results…not good.

Learned I had some spots on my lungs that needed further tests.

 

Stage 4 Metastatic Breast Cancer

March 18, 2011:

Learned it is Stage 4 Metastatic Breast cancer that had moved to my lungs, bones and lymph nodes.

Started New Chemo

April 8, 2011:

Started new chemo.

Abraxane

Abraxane, the brand name for the paclitaxel protein-bound suspension, is a drug used to treat metastatic breast cancer. It has been shown to be more effective than Taxol in treating metastatic breast cancer, with fewer side effects, states breastcancer.org. This drug is administered intravenously over half an hour, every three weeks, according to the American Cancer Society; the exact dosage depends on how much you weigh and how tall you are, your blood counts and your response to the drug. Side effects of Abraxane can include lowered white and red blood cell counts, which can lead to increased risk of infection and anemia; nausea or vomiting; hair loss; fatigue; and lip or mouth sores. This medication can also cause neuropathy in the hands and feet, which is nerve damage and feels like pins and needles, with tingling or burning in the extremities, or sensitivity to hot or cold temperatures.

Read more: http://www.livestrong.com/article/191571-chemotherapy-drugs-for-metastatic-breast-cancer-in-the-lung/#ixzz2WC3WHgBH 

I also get/continue to receive Zometa once every 6-8 weeks. This is to help strengthen my bones to keep the cancer out.

Abraxion Continues

May, 2011:

I continued on with abraxion every other week.

PET Scan

May 26, 2011:

my PET scan showed GREAT improved.

We decided to stay on the abraxion until my next scan.

Big Update

July, 2011:

The spot that we thought had shrunk had actually grown – back to the drawing board with chemo choices.

Started carboplatin and gemcitabine.

Gemzar is the brand name of the chemotherapy drug known as gemcitabine, which is commonly used to treat pancreatic cancer, non-small cell lung cancer, bladder cancer, ovarian cancer and metastatic breast cancer. It is often used in combination with other chemotherapy medications as, according to Cancer Research and Treatment, it is tolerated well by patients and produces few long-term side effects

Read more: http://www.livestrong.com/article/41409-gemzar-chemo-side-effects/#ixzz2WC5T4RqL

Carboplatin is a chemotherapy medication given to cancer patients typically through intravenous infusion. According to the MayoClinic.com carboplatin treats several types of cancer including bladder, breast, lung, testicular, brain, skin, ovarian and endometrial. Chemotherapy is designed to kill cancer cells but unfortunately kills the body’s normal cells also which causes side effects.

 

Nausea and vomiting
Nausea and vomiting occurs due to effected receptors in the brain and damage of the stomach lining. The Chemotherapy Source Book states that nausea and vomiting are common side effects of carboplatin. Nausea typically occurs 24 hours after infusion but also less commonly occurs several days after chemotherapy.

Read more: http://www.livestrong.com/article/131554-carboplatin-chemo-side-effects/#ixzz2WC65tVVW

 

BSI 201
I was also accepted on a trial drug – BSI 201

The purpose of the study is to assess the safety and establish the maximum tolerated dose (MTD) of the combination of BSI-201 with chemotherapeutic regimens in adult subjects with histologically or cytologically documented advanced solid tumors.

Based on data generated by BiPar/Sanofi, it is concluded that iniparib does not possess characteristics typical of the PARP inhibitor class. The exact mechanism has not yet been fully elucidated, however based on experiments on tumor cells performed in the laboratory, iniparib is a novel investigational anti-cancer agent that induces gamma-H2AX (a marker of DNA damage) in tumor cell lines, induces cell cycle arrest in the G2/M phase in tumor cell lines, and potentiates the cell cycle effects of DNA damaging modalities in tumor cell lines. Investigations into potential targets of iniparib and its metabolites are ongoing.

During this time, I had to get 2 blood transfusions because my white blood cell counts got so low.

NED!

December, 2011:

I was able to start just the BSI trial drug because my counts were so low and not bouncing back AND I was NED – No Evidence of Disease – means no cancer was showing up on scans!!!!

I continued on BSI 2 times a weeks and life was clicking along.

Hello, Bill

August, 2012:

My right leg went numb and for me to move my right side took so much thought…I knew something was wrong.

After going to the ER and an MRI, we found out I had a mass in my brain.

Brain Surgery

September, 2012

Had brain surgery to remove mass.

It was the same breast cancer that had moved to my brain.

Steroids & Intuition

October, 2012

Had brain radiation.

Went crazy from steroids – had to be put in the hospital for monitoring.

 

Had several more MRI because I just felt something was not right.

Bill Is Back

November, 2012:

Found out the tumor was back…same spot.

2nd Brain Surgery

November 28, 2012:

2nd brain surgery.

This one was a little more invasion to ensure he had it all.

I woke up not being able to feel my right side and couldn’t walk without a walker.

Christmas Miracle!

December 24, 2012:

Christmas Eve God told me to walk with just my cane – I did it and kept doing it!

Walking & Driving Again

January, 2013:

I started physical therapy to help with my walking.

I started practicing driving in a parking lot – I had to teach myself how to drive with 2 feet…I still drive this way!

Slowly Healing

February, 2013:

We were on our own – my mom had left and Eric’s parents left – it was time to figure out our new normal.

Another MRI – showed my brain was healing from radiation and surgeries.

Ulcer

March, 2013

I walked around the block by myself – no cane!!

PET scan showed a spot on pancreas – after MANY test and a scope later, we found out it was an ulcer…I will take an ulcer any day!

Here We Go Again…

May, 2013:

My right leg went numb again and I knew – something was wrong.

Brain Surgery Number Three

May 16, 2013:

Had third brain surgery.

Home & Updates

May 17, 2013:

I was able to go home – I guess I am getting good at recovering from brain surgery!?!?

Yes, I was able to walk.  My leg felt (and still feels) heavy and asleep, but I now know and trust it will do what it needs to do in order for me to walk on it.

Met with brain radiation Dr to talk about brain radiation to clean up area.

Got kicked off my trail drug – had very mixed emotion about this.

Radiation Mask

May 29, 2013:

I got my radiation mask made (see it here).

MRI

May 30, 2013:

Another MRI to “map the area” for radiation.

Brain Oncologist Visit

June, 2013:

Brain oncologist – he is sending in every last piece of sample tissue they have taken for over 250 other possible markers.

I have a feeling that this has something to due with hormones even though I am classified Triple Negative…this research will give us more insight to this.

Brain Radiation Treatments

June 5-7, 2013:

Had 3 brain radiation treatments.

Recovery

June 15, 2013:

I am still recovering from surgery and radiation – I am tired but not exhausted which is nice.

Seizure

September 30, 2013:

Had small seizure but it was determined NON cancerous.

Narcosis Swelling

December, 2013:

Had narcosis swelling – symptoms mimic those of tumor.

Another Encounter with Narcosis Swelling

April, 2014:

Had narcosis swelling again.  We were scheduled to go on cruise but had to cancel.

Cancer-Free Milestones!

January, 2015:

3 years of being cancer free in my body!!

18 months of being cancer free in my brain!

Rushing For Treatment

March, 2016:

My white counts started dropping drastically. Dr. H took me off Xeloda to see if they would come back up…they didn’t. She ordered a bone marrow biopsy to what was going on.

It came back positive as MDS or pre-leukemia.

Here was the problem with that, I HAD to get treatment for this or I had 18 months. Then, everyone was afraid the original breast cancer would come back. 

It took Dr. H a few attempts for her to find a bone marrow transplant doctor to do this…being Stage 4, having had 3 brain surgeries most of them didn’t want to touch me with a 10 foot pole. BUT she found Dr. Barryman in Dallas. We met, he said yes and we were off. 

Next we had to find a donor match. This happened in record time…they found 4 PERFECT matches, and before I knew it I had the transplant date: October 30. 

Bone Marrow Transplant

October 30, 2016:

Bone marrow transplant date!

Cancer-Free!

January 1, 2017:

I am home from the hospital and all my blood test are coming back great!

Not Fun Birthday Surprise

May 13, 2013:

I turned 35…and what a treatment!

Got an MRI and it showed the tumor was back in the same spot.


Cancer Terms and FAQ

In non-cancer people terms – hey, I would have NEVER understood this stuff if I weren’t living in Cancerland.

Cancer that has taken up residence in OTHER places of the body than it began. Me for example: my cancer started in my breast and I was clean and clear.

2 years later THE SAME CANCER (still breast cancer) had spread to my lungs, lymph nodes and bones.

About a 18 months after that, it again spread to my brain.

Stages of breast cancer range from stage 0 – stage 4
Some smart people know how to compare samples of the tumors – I guess – really, I don’t know how they compare cancer.
No it isn’t. It is called breast cancer that metastases to the brain, lungs, bones, etc.

It is still made up of breast cancer cells.
It is a “Positron Emission Tomography”…and no, I didn’t know that…I looked it up!

Here is how I understand it to work…they inject me with biologically active sugar water and if there are cancer cells, they drink it up the sugar water. Then when they run me through the scanner, if any cells are lite up, the scanner sees them – which are cancer cells.

In medical terms:

The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule.

Three-dimensional images of tracer concentration within the body are then constructed by computer analysis. In modern scanners, three dimensional imaging is often accomplished with the aid of a CT X-ray scan performed on the patient during the same session, in the same machine.

If the biologically active molecule chosen for PET is FDG, an analogue of glucose, the concentrations of tracer imaged then give tissue metabolic activity, in terms of regional glucose uptake.

Information from: http://en.wikipedia.org/wiki/Positron_emission_tomography
No. The needle they use to inject the “magic” stuff is very small.
I get a PET scan once every 9 – 12 weeks.

I now get MRIs once every 4 weeks.
Through my port-a-cath. It was surgically implanted when I first started this.  They poke me in the chest and hook me up to an IV.
The drug I am on, I go Monday and Thursday – 2 weeks on and 1 week off.

Different treatments call for different frequencies.
The chemo I am on now feels like I am pregnant – that under laying tired feeling and if I don’t eat often I will feel queasy.

Some past chemo meds made me feel like complete crap, so this is a walk in the park compared to those.
It is a pain – just like going to work would be a pain. We look at me going to treatment as my job, it is something I have to do and it is what it is.

I would SO much rather be NED, be on this drug an go 2 times a week.
NO EVIDENCE OF DISEASE – the BEST thing you can ever read written on a test report!
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